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    Fluconazol wirkt in therapeutischen Dosen in der Regel fungistatisch, kann aber – abhängig von der Dosis – bei manchen Organismen auch eine fungizide Wirkung vorweisen. Wie andere Imidazol- und Triazolderivate hemmt Fluconazol die 14-alpha-Demethylase des Cytochrom P450-Systems der Pilzzelle. Dadurch wird die Umwandlung von Lanosterol zu Ergosterol unterbrochen, was zu Membrandefekten der Pilzzelle führt. Die menschliche Demethylase wird durch Fluconazol deutlich schwächer gehemmt. (außer Candida krusei, Candida glabrata, Candida norvegensis und Candida inconspicua), Cryptococcus neoformans, Epidermophyton spp., Microsporum spp. Eine therapeutische Lücke besteht auch für Schimmelpilze und dimorphe Pilze. Fluconazol ist wirksam gegen ein breites Spektrum von pathogenen Pilzen, u. Häufigste Nebenwirkungen von Fluconazol sind Übelkeit, Erbrechen und Durchfall sowie die Erhöhung bestimmter Enzyme wie Aminotransferasen und Alkalische Phosphatase, selten kommt es zu schweren Leberschädigungen. Fluconazol ist ein starker Inhibitor von CYP2C9 und ein schwacher Inhibitor von CYP3A4. Es resultiert ein Risiko für Wechselwirkungen mit zahlreichen Wirkstoffen, die ebenfalls häufig mittels dieser Enzyme verstoffwechselt werden. clonidine for sleep in children Fluconazol (generisch geneesmiddel) is een geneesmiddel uit de triazolenfamilie, dat gebruikt wordt bij de behandeling van oppervlakkige en systemische infecties van gisten en schimmels. Fluconazol is ontwikkeld door Pfizer en kwam voor het eerst op de markt in 1990. Inmiddels is het verkrijgbaar als goedkoop generiek geneesmiddel. Het komt voor op de modellijst van essentiële geneesmiddelen van de Wereldgezondheidsorganisatie, waarop de belangrijkste geneesmiddelen staan die noodzakelijk zijn in een basisgezondheidssysteem. Het is verkrijgbaar als tablet en als suspensie voor oraal gebruik en ook als infusievloeistof. De stof is opgenomen in de lijst van essentiële geneesmiddelen van de WHO. Fluconazol is primair fungistatisch, maar kan fungicidaal zijn tegen sommige schimmels op een dosis-afhankelijke manier, bijvoorbeeld Cryptococcus.

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    Uses. Fluconazole is used to prevent and treat a variety of fungal and yeast belongs to a class of drugs called azole antifungals. It works by stopping the growth of certain types of. buy ventolin online europe Веро-Флуконазол, Дифлазон, Дифлюзол, Дифлюкан, Лунизол-сановель, Медофлюкон, Микомакс. Diflucan Fluconazole Wikipedia Generic and Brand Viagra-Cialis-Levitra online without Prescription. Learn about the risks, plus how to stay safe while taking your.

    These classification codes are intended as a general guide only. The effects of a substance can vary considerably depending on factors such as quantity, concentration and, in the case of herbal extracts, the part of the plant used. Even the method of extraction can make a difference, so it is important to read the details for each item. An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia: Helminths]An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia: Helminths]An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia: Helminths] by inhaling a lot of nitrous oxide over the course of an hour, and reported that, although he got a headache and giggled a lot, none of his worms were harmed. SINCE ORAL ABSORPTION IS RAPID AND ALMOST COMPLETE, THE DAILY DOSE OF DIFLUCAN (FLUCONAZOLE) IS THE SAME FOR ORAL (TABLETS AND SUSPENSION) AND INTRAVENOUS ADMINISTRATION. In general, a loading dose of twice the daily dose is recommended on the first day of therapy to result in plasma concentrations close to steady-state by the second day of therapy. The daily dose of DIFLUCAN for the treatment of infections other than vaginal candidiasis should be based on the infecting organism and the patient's response to therapy. Treatment should be continued until clinical parameters or laboratory tests indicate that active fungal infection has subsided. An inadequate period of treatment may lead to recurrence of active infection. Patients with AIDS and cryptococcal meningitis or recurrent oropharyngeal candidiasis usually require maintenance therapy to prevent relapse. The recommended dosage of DIFLUCAN for oropharyngeal candidiasis is 200 mg on the first day, followed by 100 mg once daily.

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