Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine dose during pregnancy Chloroquine phosphate dosage reef Been off of plaquenil for about 5 months and I can tell difference of my sleep. I sleep more hours during those periods I stop taking plaquenil. Now, that I am back taking plaquenil I could hardly sleep. I think I just sleep 2 hours or less or a little bit more than 2 hours each night. Does anyone. Plaquenil gave me anxiety and I could not sleep while taking a higher dose. You should probably call your doctor and tell them. Maybe they can adjust your milligrams to a lower dose to see if that is what is causing the insomnia. It is no fun not to be able to sleep, i hope you get this figured out and get some rest - Plaquenil is sometimes given only once per week. Choose the same day each week to take this medicine if you are on a weekly dosing schedule. Take Plaquenil with a meal or a glass of milk. To prevent malaria Start taking Plaquenil 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil sleep problems Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Insomnia and Plaquenil? Hydroxychloroquine sulphate tabletsDisease modifers and how to know when plaquenil is working Mar 14, 2012 Hi Missy I don't have problems going to sleep with the plaquenil, but I do have increasngly bizarre dreams - not frightening, but very odd. I can cope with these though, because the plaquenil has been a Godsend. Plaquenil and Sleep - Sjogren's World. Plaquenil Uses, Dosage & Side Effects -. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Can I take Plaquenil at night. I haven't taken it in awhile but I'm sure I've taken it at night with no problems. Bev. it helps make me sleepy so I can sleep. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. With all of the physical and emotional complications that lupus can cause, it’s easy to overlook symptoms that seem minor at first. But take this advice Don’t ignore changes in vision. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage.