She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Maqular degeneration plaquenil Success with plaquenil Chloroquine drug card Intermittent preventive therapy chloroquine In SD-OCT, the so-called “flying saucer sign” can be seen in these patients. This sign is caused by the loss of the perifoveal ellipsoid line, perifoveal thinning of the external nuclear layer and an apparent posterior displacement of the external retina structures towards the pigment epithelium, combined with the preservation of the ellipsoid line in the foveal region, producing said flying saucer sign. 5, 6 Download Citation SD-OCT As screening test for hydroxychloroquine retinopathy The flying saucer sign Two asymptomatic women treated with hydroxychloroquine 200mg every day for 8 and 16. Plaquenil Toxicity OS OCT. Download 116.3 kb File number 26573. Comments. Sign in to comment. By John S. King, MD Retina Associates, PA. HD OCT of pt with 6 year hx of plaquenil use. "flying saucer" sign Related files. Retina Image Bank. A project from the American Society of Retina Specialists Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Flying saucer sign oct plaquenil Pacific University College of Optometry, SD-OCT As screening test for hydroxychloroquine retinopathy. Chloroquine diphosphate salt chem-impexHydroxychloroquine q feverCan plaquenil cause weight lossDoes hydroxychloroquine stop hair loss SD-OCT enables the detection of early loss in external layers and lines, remaining intact below the fovea the flying saucer sign. In 10% of HCQ early toxicity cases, the most specific and objective test SD-OCT could yield false negatives, and for this reason it is important to combine this test with visual field. SD-OCT as screening test for hydroxychloroquine retinopathy.. Plaquenil Toxicity OS OCT - Retina Image Bank. OCT The Optometrist’s MREye - Tennessee Association of.. Oct 21, 2010 All three demonstrated characteristic perifoveal outer retinal abnormalities seen on SD OCT that we have termed the “flying saucer” sign; these findings include preservation of the outer retinal structures in the central fovea, perifoveal loss of the photoreceptor IS/OS junction and outer retinal thinning, posterior or “sinkhole” displacement of the inner retinal structures toward the retinal pigment epithelium, 25 and variable loss of the normal foveal depression. An electroretinogram showed bilateral absent or grossly reduced rod function and grossly reduced cone function. An OCT scan demonstrated the previously described “flying saucer” sign observed in patients with hydroxychloroquine-induced maculopathy. There is preservation of the RPE and external limiting membrane, and downward displacement of overlying inner retinal layers, sometimes described as the flying saucer sign. In most cases, the SD-OCT findings correspond to HVF 10-2 and fundoscopic examination abnormalities 28, although in some cases SD-OCT changes may precede any other abnormality 80, 81.