Increase in malaria deaths after chloroquine failure

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    Increase in malaria deaths after chloroquine failure


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    Malaria is a serious, life-threatening, and sometimes fatal, disease spread by mosquitoes and caused by a parasite. Malaria was a significant health risk in the U. S. until it was eliminated by multiple disease-control programs in the late 1940s. The illness presents with flu-like symptoms that include high fever and chills. Chloroquine is the most widely prescribed antimalarial in the world, yet there is virtually no consensus on how it should be administered to patients with cerebral malaria. Anecdotal reports of sudden death following intramuscular chloroquine administration to severely ill children have led some to recommend that parenteral chloroquine should. Malaria remains one of the most important infectious diseases in the world, being a significant public health problem associated with poverty and it is one of the main obstacles to the economy of an endemic country. Among the several complications, the effects of malaria seem to target the skeletal muscle system, leading to symptoms, such as muscle aches, muscle contractures, muscle fatigue.

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Accepting the NEJM cookie is necessary to use the website.

    Increase in malaria deaths after chloroquine failure

    Chloroquine Aralen - Side Effects, Dosage, Interactions., Chloroquine - an overview ScienceDirect Topics

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  4. Cyclosporine After introduction of Chloroquine oral form, a sudden increase in serum cyclosporine level has been reported. Therefore, close monitoring of serum cyclosporine level is recommended and, if necessary, Chloroquine should be discontinued. Mefloquine Co-administration of Chloroquine and mefloquine may increase the risk of convulsions.

    • Chloroquine - FDA prescribing information, side effects and uses.
    • The effect of malaria and anti-malarial drugs on. - Malaria Journal.
    • Impact of chloroquine resistance on malaria mortality..

    Severe malaria occurs when an infection is complicated by serious organ failure or abnormalities in the patient’s blood or metabolism. More on Malaria Symptoms – Severe Malaria Patients who have severe P. falciparum malaria or who cannot take oral medications should be given treatment by continuous parenteral infusion in a hospital. Malaria Deaths Following Inappropriate Malaria Chemoprophylaxis ---United States, 2001. During January--March 2001, two U. S. citizens died from malaria after taking chloroquine alone or with proguanil for malaria chemoprophylaxis in countries with known chloroquine-resistant Plasmodium falciparum malaria. Malaria symptoms can develop as early as 7 days after being bitten by an infectious mosquito in a malaria-endemic area and as late as several months or more after exposure. Suspected or confirmed malaria, especially P. falciparum, is a medical emergency requiring urgent intervention, as clinical deterioration can occur rapidly and unpredictably.

     
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