Hydroxychloroquine weight based dosing 5 mg kg ideal bo

Discussion in 'North West Pharmacy Canada' started by IgnatGR, 04-Mar-2020.

  1. JeM Well-Known Member

    Hydroxychloroquine weight based dosing 5 mg kg ideal bo


    Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid).

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    The current recommended maximal dose for hydroxychloroquine is 6.5 mg/kg/day, with the weight in kilograms used for this calculation being the ideal bodyweight rather than actual bodyweight. The 2011 AAO guidelines recommended dosing hydroxychloroquine based on ideal body weight – what a patient should weigh for their height. This was supposed to ensure that people who were very short or overweight got the right amount of drug. The proposed daily dose was 6.5 mg per kg of ideal body weight. Acute attack 800 mg 620 mg base orally followed in 6 to 8 hours by 400 mg 310 mg base, then 400 mg 310 mg base once a day for 2 consecutive days; alternatively, a single dose of 800 mg 620 mg base has also been effective Alternate dosing based on body weight A total dose representing 25 mg/kg is administered in 3 days, as follows

    It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015.

    Hydroxychloroquine weight based dosing 5 mg kg ideal bo

    Hydroxychloroquine Blood Levels in SLE Clarifying dosing controversies., Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at.

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  3. Trends of incident hydroxychloroquine prescription dose per ideal body weight and actual body weight 2007–2016. Median and inter-quartile ranges of incident hydroxychloroquine prescription dose, calculated per mg/kg of ideal body weight and per mg/kg of actual body weight, in relation to published guideline-recommendations

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    There is an increased risk of HCQ retinopathy with increase in the cumulative dose. Per the prior 2011 AAO guidelines the recommended maximum dose to minimize HCQ retinal toxicity was 6.5 mg /kg based on ideal body weight 2. The advantage of the real body weight formula is that it distributes the risk evenly on a broad range of body habitus. SAN FRANCISCO – Hydroxychloroquine Plaquenil dosing based on actual body weight – instead of ideal weight – is appropriate for patients with systemic lupus erythematosus SLE, according to a review of 686 lupus patients at Johns Hopkins University in Baltimore. Most were dosed by actual weight, 6.5 mg/kg up to a maximum of 400 mg/day. Again, calculating "safe" daily plaquenil dosage for this weight 66.02 kg * 6.5 mg/kg/qd = 429 mg. As expected, it indicates a higher "safe" dosage 429 vs 356mg than the calculation using ideal body weight for this height. For the last time, let's graph this relationship to get a look at the big picture

     
  4. Bakin Moderator

    In some cases, they may not be available in every strength or form as the brand-name drug. Hydroxychloroquine - Alberta Rheumatology Hydroxychloroquine Plaquenil - medications for Rheumatoid. Hydroxychloroquine sulphate in the treatment of rheumatoid.
     
  5. Turizm User

    Hydroxychloroquine Prices, Coupons & Savings Tips - GoodRx HYDROXYCHLOROQUINE is used to treat rheumatoid arthritis and systemic lupus erythematosus. It is also used to treat malaria. The lowest GoodRx price for the most common version of hydroxychloroquine is around .41, 88% off the average retail price of 7.73.

    Plaquenil Hydroxychloroquine - Canada Wide Pharmacy