Effect of chloroquine injection on early pregnancy

Discussion in 'International Pharmacy' started by igor86, 16-Mar-2020.

  1. Grangel Moderator

    Effect of chloroquine injection on early pregnancy


    While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta.

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    Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm. It was observed that two corpora lutea could effectively maintain pregnancy until term and the pregnant rats did deliver viable pups by early morning on day 23 of pregnancy as recorded in controls. Injection of chloroquine in similarly surgically manipulated partially luteectomized pregnant rats resulted in complete emptying of the gravid. Chloroquine has a schizonticidal effect and kills the erythrocytic forms of malaria parasites at all stages of development, but does not affect the sporozoites inoculated by the mosquito or the malaria parasite in human liver cells.

    Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area.

    Effect of chloroquine injection on early pregnancy

    Chloroquine Oral Uses, Side Effects, Interactions, Pictures, Warnings., Chloroquine and premature evacuation of uterine conceptus.

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  6. Chloroquine or hydroxychloroquine. No harmful effects on the fetus have been observed when chloroquine or hydroxychloroquine are used in the recommended doses for malaria prophylaxis. 2 Observational data 5, 6 amounting to more than 1000 exposures and 1 double-blind randomized-controlled trial 7 N = 951 have evaluated the use of chloroquine at various stages of pregnancy for the prevention.

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    Side Effects of Early Pregnancy. Early pregnancy is a challenge as a woman very young lacks the skills to handle the phase of pregnancy and motherhood. Due to the lack of effective self-care, early pregnancy can also hamper the development of the baby. Additionally, early pregnancy can impact a woman’s social life and her mental state of mind A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Call your doctor. Use in pregnancy. There is no evidence that chloroquine is harmful in prophylactic doses during pregnancy. Because of the susceptibility of pregnant women to falciparum malaria, it should be used at the recommended dosage for both prophylaxis and treatment wherever chloroquine-sensitive malaria is prevalent. Adverse effects

     
  7. Bish0p XenForo Moderator

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Qualaquin quinine dosing, indications, interactions, adverse effects. Vitamin B12 Dosage How Much Should You Take per Day? Polio Vaccine Composition, Dosage, and Administration CDC
     
  8. evear New Member

    Download PDF Many systemic medications may cause retinal toxicity. Hydroxychloroquine Retinopathy Still Alive and Well - The. Plaquenil Side Effects on Your Eyes and Vision Autofluorescence of Basal Laminar Drusen
     
  9. paul_ryazanov XenForo Moderator

    Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells. Rare but potentially serious eye toxicity can occur.

    Hydroxychloroquine Advanced Patient Information -