At first it seemed like it helped now I feel the same as before I started taking the medicine other than the fact that none of my clothes fit and there is a lot more of me to carry around. Anyone know if I quit taking it if the weight will fall back off I started Hydroxychloroquine 2 weeks ago. One week in and I thought this may just work, except for the ‘extra itchiness’ I seemed to get every night. Plaquenil methotrexate shigles vaccine Plaquenil combination therapy Chloroquine used whee Hydroxychloroquine doesn’t work immediately. It may be 12 weeks or longer before you notice any benefit. Because it's a long-term treatment it's important to keep taking hydroxychloroquine unless you have severe side-effects even if it doesn't seem to be working at first; even when your symptoms improve to help keep the disease under control. Symptoms while waiting for hydroxychloroquine to work. How is hydroxychloroquine taken? Hydroxychloroquine is taken by mouth in tablet form. The usual dose is one tablet 200mg once or twice a day. Tablets can be taken altogether, once a day. The dose may be reduced to a maintenance dose after a few months once a response is achieved. Symptoms can start to improve in one to two months, but it may take up to six months before the full benefits of this medication are experienced. Side Effects Hydroxychloroquine typically is very well tolerated. I was prescribed this drug to ease my ra disease, I was taking 400mg per day which was to last for 3 months then reduced to 200mg. Right before I hit the two week mark, I woke up with my heart racing and continued feeling my heart flutter all day and I just felt week and tired. After msging Rheum, decided to stop taking meds to see how I feel and continue with the AIP to handle symptoms and try to work at ‘healing from inside out! Time will tell and I’m eager to see how much the AIP is helping once odd meds. Months for hydroxychloroquine to work on joints Hydroxychloroquine User Reviews for Rheumatoid Arthritis at., PATIENT NFORMATION ON HYDROXYCHLOROQUINE Taking hydroxychloroquine for lupusTests to get before starting hydroxychloroquine Hi, I started on Hydroxychloroquine 200mg a day, for undifferentiated connective tissue disease, about 3 months ago. Within 3 weeks, the eczema I have had all my life completely cleared up. Amazing! But I still haven’t had any improvement in the fatigue or joint pain. How long does Hydroxychloroquine take to work for. - LUPUS UK. Hydroxychloroquine Plaquenil. Painful Hand OA Not Relieved by Hydroxychloroquine Everyday.. The exact hydroxychloroquine mechanism of action is unclear, although it does work to interrupt the communication of immune system cells to decrease swelling, pain, and joint damage. 1, 2, 3, 5 From the community “My Rheumatologist recently put me on Hydroxychoroquine for treating osteoarthritis and joint cysts in my hands and every other. Hydroxychloroquine along with 30 mg of Prednisone worked for me within 3 months and did a great job. However I had a side reaction- hallucination, so I came off the drug. Plaquenil did not work as well for me,it took about 10 weeks before I saw some effect but again I had a reaction- my fatigue got even worse and I could not stay awake. Indicates that you can expect to see some results after a month or two of taking hydroxychloroquine, but in order to get the full benefits you will need to take the medication for at least six months. That can help you realize how much benefit you’re going to actually get from the drug.