Plaquenil retinopathy autofluorescence

Discussion in 'Hydroxychloroquine 200mg' started by Agatta, 01-Mar-2020.

  1. Plaquenil retinopathy autofluorescence


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Hydroxychloroquine HCQ is an anti-malarial medication that has in recent times been utilized as treatment for a variety of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, and other inflammatory and dermatologic conditions. Retinal toxicity from HCQ, and its analog, chloroquine, has been recognized for many years.2,3 By some estimates, in the United. Patients with abnormalities on widefield fundus autofluorescence with normal 10-2 visual field. Some patients at risk of hydroxychloroquine retinopathy may not be able to undertake the required screening tests, and in some there may be ocular co-pathology that prevents interpretable imaging. Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Plaquenil retinopathy autofluorescence

    New Plaquenil Guidelines, Hydroxychloroquine and Chloroquine Retinopathy.

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  4. Retinal Diseases; Home; Hydroxychloroquine Retinopathy-Fundus Autofluorescence. Fundus autofluorescence image of a 46-year-old woman with systemic lupus erythematosus who had taken chloroquine for 17 years at a dosage of 500 mg/d. Based on her actual body weight, which was ideal, she had been overdosed at 8.8 mg/kg/d and had received a.

    • Hydroxychloroquine Retinopathy-Fundus Autofluorescence..
    • Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy.
    • Despite Plaquenil dosing recommendations, retinal toxicity remains.

    Rheumatologists use hydroxychloroquine sulfate Plaquenil, Concordia Pharmaceuticals to treat autoimmune diseases, namely discoid or systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, and malaria. When taken at high doses and for long durations, hydroxychloroquine has been known to cause parafoveal retinal toxicity. Figure 1 is an image of an ocular fundus using autofluorescence to designate an area of retinal damage. To detect chloroquine toxicity, the American Academy of Ophthalmology recommends performing fundus examinations, 10-2 automated visual fields, and at least one objective test multifocal electroretinography mfERG, fundus autofluorescence. Bull’s Eye Retinopathy Early macular toxicity can cause stippling or mottling of the RPE Next, granular pigmentation and loss of the normal foveal reflex can occur It’s believed but not proven that if early macular changes are detected and the medication is stopped, any toxicity that has occurred can be reversed.1 If the maculopathy continues to progress, concentric zones of.

     
  5. Marina_M Moderator

    Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Plaquenil, Plaquenil Sulfate, Quineprox hydroxychloroquine. What is Plaquenil? - GoodRx Plaquenil Uses, Dosage & Side Effects -
     
  6. RElena User

    Hi there, I normally post on the arthritis board, and due to toxicity of the Plaquenil after 2 years, I have had to discontinue it, since I failed the visual field testing. I'm sure you do feel like you're losing your mind.(((hugs)))Pat Hi there, I had put a posting about this a few weeks ago on here. Alternatives to plaquenil Anti-Inflammatories discussions Therapies. I am so afraid to take plaquenil for lupus treatment! any. Is there an alternative to Plaquenil?
     
  7. pavel-jazz New Member

    Hydroxychloroquine - Wikipedia Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda.

    Who discovered chloroquine - Answers