In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Plaquenil caused seizures Plaquenil and vision Plaquenil overdose treatment Sep 13, 2019 Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. The side effect that is of greatest concern is retinal toxicity. Beyond Plaquenil Other Drugs, Other Problems. If you’re looking for a comprehensive assessment of drug reactions that relate to the eye, Dr. Fraunfelder and his father, Frederick T. “Fritz” Fraunfelder, MD, along with Wiley A. Chambers, MD, literally wrote the book. 3 “So many drugs can cause ocular side effects that if you’re trying to make a point about which drugs to watch out. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Plaquenil side effects eye pain The Risk of Retinal Toxicity with Plaquenil, The Risk of Retinal Toxicity with Plaquenil - Sjogren's Hydroxychloroquine scarring alopeciaPlaquenil causing hearing loss Side effects include digestive problems, skin rash and disorders of skin pigmentation. One of the most serous side effects includes disorders of eyesight. The side effects related to the eyesight are blurred vision, sensitivity of the eyes to sun light, decreased night or color vision, decreased ability to see objects at the edge of vision, black spots in the vision or light flashes or streaks. Side effects of Plaquenil Other Drugs discussions.. Rx Side Effects New Plaquenil Guidelines and More.. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Lower back or side pain. noisy breathing. painful or difficult urination. red irritated eyes. red skin lesions, often with a purple center. severe mood or mental changes. sore throat sores, ulcers, or white spots on the lips or in the mouth. sticking out of the tongue. stomach pain. swelling of the feet or lower legs. swollen or painful glands Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells. Rare but potentially serious eye toxicity can occur. RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells.