It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Chloroquine prevention malaria Can hydroxychloroquine cause sexual dysfunction How does plaquenil fight malaria Plaquenil induced bruising on shins If you're taking Plaquenil for an autoimmune condition, your symptoms should begin to improve after a few months, but it can take up to six months for full effects. Stop taking the medicine and. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Jan 30, 2018 Hi, I've been taking Plaquenil for many years now and have never experienced any side effects or long term effects. But headache is listed as one of the "mild adverse effects". I would suggest that you try to split the dose as suggested. I've always taken 1 in the AM & 1 at night. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Long-term effects of taking plaquenil Long-Term Side Effects of Plaquenil for Rheumatoid., Plaquenil Side Effects Common, Severe, Long Term - Plaquenil for vasculities rashWhy is chloroquine used to treat lupus In this review, we analyze Plaquenil side effects by the time on the drug, gender and age of the people who have side effects while taking Plaquenil. The review is based on 48,938 people who have side effects while taking the drug from Food and Drug Administration FDA. Common Plaquenil side effects a study from FDA data.. Plaquenil side effects question - Scleroderma - Inspire. Plaquenil Hydroxychloroquine Side effects, Images, Uses.. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. As PLAQUENIL may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin or antidiabetic drugs may be required. Drugs That Prolong QT Interval And Other Arrhythmogenic Drugs. PLAQUENIL prolongs the QT interval and should not be administered with other drugs that have the potential to induce cardiac arrhythmias.