It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Plaquenil fever Chloroquine alcohol use Can hydroxychloroquine be crushed The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. Hydroxychloroquine is an antimalarial drug which is relatively safe and well-tolerated agent for the treatment of rheumatoid arthritis. Chloroquine is another antimalarial agent that is also sometimes used. Dosage for rheumatoid arthritis Adult dosage ages 18 years and older Typical starting dosage 400–600 mg per day, given as a single daily dose or in two 2 divided doses. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Hydroxychloroquine 400 mg for rheumatoid arthritis What are the side effects of using hydroxychloroquine., Rheumatoid Arthritis Treatment Options Johns Hopkins. Plaquenil and lymphomaLong-term effects of taking plaquenilChloroquine rheumatoid arthritisWhat do hydroxychloroquine do Abstract. A controlled, double blind, parallel group, long term study of hydroxychloroquine sulphate in the treatment of rheumatoid arthritis, comparing daily doses of 200 mg and 400 mg, is described. The trial involved 54 patients with moderate disease activity who had not previously received antimalarial drugs. Hydroxychloroquine sulphate in the treatment of rheumatoid.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine Plaquenil. For the treatment of RA, hydroxychloroquine is typically taken by mouth once daily at 200-400 mg, although it can be taken at a higher dose. A loading dose of 1,200 mg daily, given for 6 weeks may decrease the time to clinical response. However, experts debate that this higher dosage may increase the risk of toxicity. The 100 patients assessed through the nine-clinic audit process averaged 58 years old, 81% were women, and patients had been taking HCQ for an average of just over 6 years, primarily for rheumatoid arthritis or systemic lupus erythematosus. Nearly two-thirds had a high risk for retinal toxicity. The recommended hydroxychloroquine dosage for rheumatoid arthritis is 400 mg to 600 mg a day by mouth as a single dose or divided into two separate doses. However, once a good response is being maintained with hydroxychloroquine, doses may be reduced to 200 mg to 400 mg per day for maintenance.