She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Chloroquine pills Side effects of discontinuing plaquenil Can you take plaquenil as needed Cost of plaquenil at costco Hydroxychloroquine retinal toxicity is far more common than previously considered; an overall prevalence of 7.5% was identified in patients taking HCQ for greater than 5 years, rising to almost 20. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Executive Summary Recent data have highlighted that hydroxychloroquine retinopathy is more common than previously reported. The prevalence in long term use patients appears to be around 7.5% and depending on dose and duration of Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Hydroxychloroquine retinopathy prevalence The Risk of Hydroxychloroquine Retinopathy in an SLE., Hydroxychloroquine-Induced Retinal Toxicity - American. Symptoms of plaquenil eye problemsHow immunosuppressant is hydroxychloroquineHypoglycemia and plaquenil The prevalence of hydroxychloroquine retinopathy HCR is important to know because it provides the justification for screening the estimated 350 000 Americans who take the drug. No methodologically sound epidemiologic study of the issue has been done, but many estimates of prevalence have been made, and in the last 20 years their size has increased dramatically. From 1983 to 2003, the. The Prevalence of Hydroxychloroquine Retinopathy and Toxic.. Hydroxychloroquine and Chloroquine Retinopathy.. Incidence of and risk factors for chloroquine and.. The risk of ocular toxicity increases with the cumulative hydroxychloroquine dose. The prevalence of retinopathy in those using the drug less than 10 years is less than 2%; in contrast, the prevalence in patients with more than 20 years of exposure is reported to be as high as 20%. 26 These guidelines were based on evidence that the prevalence of retinopathy in long term use patients appears to be around 7.5% and depending on dose and duration of therapy can increase to 20–50. These recommendations are based primarily on one retrospective cohort study that reported a much higher prevalence of HCQ retinopathy 7.5%, n = 2361 than previously observed 0.5–2.0%. Incidence of hydroxychloroquine retinopathy in 1,207 patients in a large multicenter outpatient practice.