Chloroquine phosphate drug study

Discussion in 'Chloroquine Phosphate' started by SlashP, 27-Feb-2020.

  1. bigbadaboom Guest

    Chloroquine phosphate drug study


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    The study is a double-blind, randomised, placebo-controlled trial that will be conducted in health care settings. After obtaining fully informed consent, the investigator will recruit healthcare workers, or other individuals at significant risk who can be followed reliably for 5 months. 10,000. Chloroquine, a medication used to prevent and to treat malaria, has just been confirmed as one of the three anti-viral drug for Coronavirus. The search for the cure of Coronavirus has been on for some time The coronavirus disease 2019 COVID-19 virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine phosphate drug study

    Delingpole Studies Claim Malaria Drug Chloroquine Effective., Chloroquine confirmed as anti-viral drug for Coronavirus

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  4. The dosage of Chloroquine phosphate is often expressed in terms of equivalent Chloroquine base. Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight.

    • Chloroquine - Prescription Drug Information..
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    • Chloroquine phosphate C18H32ClN3O8P2 - PubChem.

    Encouraging news a new medical study shows a commonly available anti-malaria drug known as chloroquine aka chloroquine phosphate is showing strong results against COVID-19 infections in both China and South Korea. The study outlined that in clinical trials in China, chloroquine, an FDA-approved drug for the treatment of malaria, was effective and safe in dealing with COVID-19 associated pneumonia in a lab dish. This triggered a spread of anticipation throughout the world about a possible treatment for the pandemic virus. Chloroquine is an immunosuppressive drug and anti-parasite commonly used in malaria treatment. It’s most often taken as a tablet by mouth.

     
  5. flame-scarlett New Member

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  6. voffki-net New Member

    There are three major isoforms of the ryanodine receptor, which are found in different tissues and participate in different signaling pathways involving calcium release from intracellular organelles. Chloroquine Side Effects Common, Severe, Long Term. PLOS ONE Chloroquine Is a Zinc Ionophore The autophagy inhibitor chloroquine targets cancer stem.
     
  7. Natalya56 New Member

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