Approximately 4 months after his arrival he begins to experience episodes of flu-like symptoms including fever, chills, fatigue and sweating. He goes to local free health clinic, where he is diagnosed with malaria, and given a prescription for chloroquine. Hydroxychloroquine lysosome blocker Plaquenil drug information Hydroxychloroquine puffy eyes Benefits of plaquenil for lupus Malaria Mode of action of chloroquine and mechanism of chloroquine resistance Article PDF Available in Journal de Pharmacie Clinique 323143-153 September 2013 with 415 Reads Antimalarial mode of action and resistance. Chloroquine acts exclusively in the erythrocyte stage of malaria parasites. The antimalarial mechanism of action from chloroquine has not been fully elucidated. General antimicrobial mechanism of action of chloroquine. Chloroquine accumulates in very high concentrations in the parasite food vacuole Geary et al. 1986. Once in the food vacuole, chloroquine is thought to inhibit the detoxification of heme. Chloroquine becomes protonated to CQ 2+ because the digestive vacuole is acidic pH 4.7 In 2012 the CDC estimated there were 627,000 estimated deaths due to malaria (CDC: Malaria, 2015). His symptoms disappear soon after beginning chloroquine therapy, but several months later his symptoms reappear., and one of the leading causes of death and disability (Figure 1). Mechanism of action of chloroquine in malaria How does methylene blue’s mode of action differ from chloroquine in., Chloroquine Modes of action of an undervalued drug. Sanofi aventis plaquenilChloroquine and proguanil malariaPlaquenil erosive arthritis Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Chloroquine Oral Uses, Side Effects, Interactions, Pictures, Warnings.. Antimalarial drugs Mode of action and status of resistance. On the molecular mechanism of chloroquine's antimalarial action. Antiprotozoal-Malaria /Mechanism of action/ may be based on ability of chloroquine to bind and alter the properties of DNA. Chloroquine also is taken up into the acidic food vacuoles of the parasite in the erythrocyte. It increases the pH of the acid vesicles, interfering with vesicle functions and possibly inhibiting phospholipid metabolism. In this review, a hypothesis is presented that can explain much of the confusing detail concerning the Chloroquine in Plasmodium faleiparum 205 specific antimalarial action of chloroquine. As the mechanism of action appears to be distinct from the mechanism of resistance, this identifies a vulnerable target for the development of new. Malaria infection associated with travel. Center for Global Health Division of Parasitic Diseases and Malaria. Who can take chloroquine? Chloroquine can be prescribed to adults and children of all ages. It can also be safely taken by pregnant. women and nursing mothers. Who should not take chloroquine? People with psoriasis should not take.