Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine hydrochloride formulation Hydroxychloroquine with methotrexate combination Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia. Has anyone had any visual disturbances as a result of being on Plaquenil? I have had a few instances of this occurring and it was very disorienting and scary. The information given to me by the rheumatologist said that visual disturbances could occur. I was just wondering if anyone else has experienced it too. Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3 The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Visual prolem with plaquenil Eye screening for patients taking hydroxychloroquine Plaquenil, Visual disturbances with Plaquenil Has anyone had. - LUPUS UK Hydroxychloroquine induced drug rashHydroxychloroquine eyeDrugs for ra plaquenil andHydroxychloroquine retinopathy riskPlaquenil screening guidelines ophthalmology A rare side effect of Plaquenil involves visual changes or possible loss of vision—the side effect that is most worrisome for patients. The aforementioned rare side effect that affects vision hydroxychloroquine retinopathy, if caught early, may improve after discontinuation of Plaquenil. Taking Plaquenil for Rheumatoid Arthritis. New Plaquenil Guidelines. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Aug 01, 2009 My mother was diagnosed with Plaquenil Toxicity in 2007 she first noticed changes in 2006, although being followed by her eye doctor they failed to notice this as Plaquenil TX until it was to late. After the medicine was Discontinued she continued to have more and more visual changes for the worse and still is declining in her vision. In rare cases, hydroxychloroquine can cause visual changes or loss of vision. Such vision problems are more likely to occur in individuals taking high doses for many years, individuals 60 years or older, or those with significant kidney disease. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs.