The most commonly used DMARD is methotrexate (Trexall®, Rheumatrex®, Otrexup®, Resuvo®). Other DMARDs include sulfasalazine (Azulfidine®), leflunomide (Arava®), hydroxychloroquine (Plaquenil®), Cyclosporine (Neoral®, Sandimmune®), Azathioprine (Imuran®), and Apremilast (Otezla®). Plaquenil and liver disease Chloroquine review CHICAGO – Combination therapy with leflunomide and hydroxychloroquine met all goals for efficacy, safety, and tolerability among patients with primary Sjögren’s syndrome in a randomized, placebo-controlled pilot study, lending support to evidence suggesting the two drugs have additive benefits. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Fuerst and co-workers noted the risk of postoperative wound healing complications in patients undergoing leflunomide therapy was significantly higher than in patients undergoing alternative treatments with methotrexate.17 These authors reported a 40.6 percent complication rate in patients undergoing leflunomide therapy in comparison to a 13.6. This prevents some cells in your body from reproducing themselves. Methotrexate works by blocking enzymes that help DNA (genetic material in the cells of your body) form or repair. Leflunomide methotrexate and hydroxychloroquine Combination Therapy for Rheumatoid Arthritis in the Era of., Rheumatoid Arthritis Treatment Options Johns Hopkins Arthritis Center Do hydroxychloroquine get you high Background/Purpose The combination of methotrexate MTX, sulfasalazine SSZ and hydroxychloroquine HCQ triple therapy is a highly effective and well-tolerated treatment in rheumatoid arthritis RA. While MTX is the cornerstone of most successful combination therapies, not all patients are candidates for, or tolerate, MTX. Leflunomide, a disease-modifying anti-rheumatic drug DMARD. Leflunomide, Sulfasalazine and Hydroxychloroquine for Rheumatoid.. A Guide To Perioperative Management Of The Rheumatoid Patient.. Anyone on Leflunomide, Hydroxychloroquine and MTX? - NRAS. The U. S. Food and Drug Administration FDA is adding information on severe liver injury to the Boxed Warning of Arava leflunomide – a drug used to treat rheumatoid arthritis - to. Leflunomide is the generic form of the brand-name medicine Arava, which is used to treat rheumatoid arthritis a condition in which the body attacks its own joints. This prescription medication. Among those who were on leflunomide, four were on a single drug while one also received methotrexate. Both patients in the other group were on methotrexate and hydroxychloroquine. The onset of neuropathy was on an average 3 months range 45 days to 120 days after the initiation of leflunomide.