Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil rash how long Ranbaxy hydroxychloroquine Lysosomal inhibitor chloroquine Some patients decide to stop taking statins, a cholesterol-lowering drug, if they experience side effects. A new study tracked how they did. According to Drugs.com, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg. Re Methotrexate vs Plaquenil side effects long term and short term The MTX dose for autoimmune disease is about 1/1000 the dose they use in cancer patients. MTX also has a long clinical history, which makes it a trustworthy drug, they'll be no "surprise" side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. How long do side effects of plaquenil last Hydroxychloroquine Plaquenil, Long-Term Side Effects of Plaquenil for Rheumatoid. Chad hummel ophthalmologist plaquenilSle hydroxychloroquinePlaquenil 200 mg film-coated tabletsPlaquenil and vasculitis Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Incidence not known. Blistering, peeling, loosening of the skin. blurred vision or other vision changes. chest discomfort, pain, or tightness. cough or hoarseness. dark urine. decreased. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Methotrexate vs plaquenil side effects long term and short.. Common and Rare Side Effects for Plaquenil Oral. When I increased to 200mg/day, I had strange side effects that caused me to go back to 100/day. Strange leg cramping, restless leg, nausea and anxiety. In a nutshell, at 200mg/day the side effects outweighed the benefits. At 100mg/day, I do not have 100% reduction in my symptoms, but I have enough of a reduction to want to continue the. What are the side effects of Plaquenil? The most common side effects are diarrhea, nausea, vomiting, headache, dizziness, skin rash or black spots when you look at things. Most side effects will go away when your body gets used to the medicine. Tell your doctor if you have these side effects. A lower dose may stop them. Do not lower the dose on. What are the side effects of Plaquenil? • The most common side effects are diarrhea, nausea, vomiting, headache, dizziness, skin rash or black spots when you look at things. • Most side effects will go away when your body gets use to the medicine. •Tell your doctor if you have these side effects. A lower dose may stop them.