Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Hydroxychloroquine-mediated retinopathy Chloroquine rapamacyin Deubiquitinating enzyme chloroquine Mar 15, 2019 The first reports of retinal toxicity attributed to chloroquine appeared during the late 1950s. In 1958, Cambiaggi first described the classic retinal pigment changes in a patient receiving chloroquine for systemic lupus erythematous SLE. Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis. Robert A. Mittra, William F. Mieler, in Retina Fifth Edition, 2013. Chloroquine. Chloroquine was first used as an antimalarial drug in World War II. Currently it is prescribed for treatment of amebiasis, rheumatoid arthritis, and systemic lupus erythematosus in countries primarily outside the United States, and for prophylaxis against malaria. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Chloroquine dosing for lupus retina Hydroxychloroquine-Induced Retinal Toxicity - American., Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine plaquenil direct sunlightCan swollen ankles be caused by hydroxychloroquineDifference chloroquine bafilomycin a1 Apr 02, 2019 This represents a total dose of 2.5 g chloroquine phosphate or 1.5 g base in three days. The dosage for adults of low body weight and for infants and children should be determined as follows First dose 10 mg base per kg but not exceeding a single dose of 600 mg base. Aralen Chloroquine Uses, Dosage, Side Effects.. Chloroquine Retinopathy - an overview ScienceDirect Topics. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Feb 19, 2020 The recommended adult dosage is 200 to 400 mg 155 to 310 mg base daily, administered as a single daily dose or in two divided doses. Doses above 400 mg a day are not recommended. The incidence of retinopathy has been reported to be higher when this maintenance dose is exceeded. Jan 05, 2020 Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs.