Primaquine works by interfering with the growth of parasites in the body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Plaquenil and nsaids Chloroquine drug interactions Can plaquenil cause bruising Primaquine is used after other medications such as chloroquine have killed the malaria parasites living inside red blood cells. Primaquine then kills the malaria parasites living in other body tissues. This prevents the return of the infection. Both drugs are needed for a complete cure. Before the administration of chloroquine, the patient had only a mild skin erythema in the irradiated area, which was consistent with the radiotherapy dose she had received. On day 3 of chloroquine therapy, she developed localized brisk bullous eruptions in the irradiated area, which developed into a patch of fulminant moist desquamation. Chloroquine combined with primaquine has been the standard radical curative regimen for Plasmodium vivax and Plasmodium ovale malaria for over half a century. Vivax malaria is a form of malaria in which parasites travel from the bloodstream into other cells and tissues of the body. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine and primaquine Primaquine in vivax malaria an update and review on., Chloroquine Side Effects Common, Severe, Long Term. Chloroquine dengueChloroquine dosing schedule Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Chloroquine Aralen - Side Effects, Dosage, Interactions.. Pharmacokinetic interactions between primaquine and.. Chloroquine and primaquine combining old drugs as a new.. Chloroquine-Primaquine Therapeutic Efficacy, Safety, and Plasma Levels in Patients with Uncomplicated Plasmodium vivax Malaria in a Colombian Pacific Region. Mesa-Echeverry E1, Niebles-Bolívar M1, Tobón-Castaño A1. Chloroquine is commonly under-dosed in the treatment of vivax malaria. Increasing the recommended dose to 30 mg/kg in children younger than 5 years could reduce substantially the risk of early recurrence when primaquine is not given. Chloroquine may block the entrance of potassium into the cells and primaquine also has an effect on blocking sodium channels. Both may also have an effect on the chloride channels present in cardiac myocytes, which may explain the occurrence of cardiac and gastrointestinal side effects 19.