Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine in the uterus Plaquenil retinal toxicity oct Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Patients using plaquenil may experience important but rare side effects that affect the eyes, including damage to the retina back of the eye, cornea front of the eye, and eyelids. These side effects typically occur on high doses of the medication and increase with duration of use. Although rare, Plaquenil can cause significant toxicity to the eye with prolonged use. Also, Plaquenil may have various systemic side effects that are not related to the eyes. These too are rare and include nerve weakness, hallucinations, psoriasis and changes in hair color. The eye complications are the most serious and worrisome. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Side effects of plaquenil on eyes Side effect question for plaquenil/ eyes DailyStrength, Plaquenil - Colorado Springs Eye Clinic How long to try plaquenil Plaquenil is a drug used to treat Rheumatoid Arthritis and Systemic Lupus Erythematosis. It is a very good drug and gives many patients significant relief from their symptoms. Plaquenil related eye complications are not common. Plaquenil can produce pigment changes in the macula of the retina. Conditions Plaquenil-related Eye Problems Eugene Eye Care. PLAQUENIL hydroxychloroquine and the Eye Westford. Plaquenil Side Effects Common, Severe, Long Term -. One of the most serious side effects is a toxicity in the eye generally with chronic use. People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity, whereas the risk begins to go up when a person takes the medication over 5 years or has a cumulative dose of more than 1000 grams. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. You will likely have to take additional medications to keep your rheumatoid arthritis in control.