Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine with methotrexate combination Plaquenil side effects muscle weakness Plaquenil and scleroderma Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Based on strict histological ultrastructural criteria, the diagnosis of CQ/HCQ-induced cardiomyopathy has been confirmed pathologically in only 24 patients to date. The prognosis for patients with this cardiomyopathy appears to be mixed heart transplants had to be performed in 2 patients with refractory heart failure 9,22. Thirteen patients died most of them soon after the diagnosis was established. Retinal toxicity, neuromyopathy, and cardiac disease are recognized adverse effects of hydroxychloroquine. Immediate withdrawal of hydroxychloroquine is essential if toxicity is suspected because of the early reversibility of cardiomyopathy. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil related cardiomyopathy Plaquenil Hydroxychloroquine - Side Effects, Dosage., Cardiomyopathy Caused by Longterm Treatment with. Chloroquine phosphate drug studyPlaquenil dosage autoimmune thyroiditisChloroquine defineLyrica and hydroxychloroquineWhat else can i take if i cant take plaquenil Plaquenil is a drug that has been around the longest that’s been used for lupus which means they know more about it. Which makes most doctors use it to help treat symptoms and almost eliminated a lot of those symptoms your having. Recent lupus diagnosis and contemplating Plaquenil - Lupus.. Hydroxychloroquine-induced cardiomyopathy case report.. HYDROXYCHLOROQUINE PLAQUENIL CARDIOTOXICITY AN UNCOMMON.. Chloroquine CQ and hydroxychloroquine HCQ are anti‐rheumatic medications frequently used in the treatment of connective tissue disorders. We present the case of a 45‐year‐old woman with CQ‐induced cardiomyopathy leading to severe heart failure. Dilated cardiomyopathy is a disease of the heart muscle, usually starting in your heart's main pumping chamber left ventricle. The ventricle stretches and thins dilates and can't pump blood as well as a healthy heart can. The term "cardiomyopathy" is a general term that refers to the abnormality of the heart muscle itself. Our patient likely had baseline mild proximal myopathy secondary to hydroxychloroquine with her acute decompensation due to a second myotoxic drug, colchicine. To our knowledge this is the first documented case of a myopathy induced by both hydroxychloroquine and colchicine supported by unique electron microscopy findings.