Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Does plaquenil have generic Hydroxychloroquine in g6pd deficiency Hydroxychloroquine long half life What does plaquenil do to your eyesight These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Get medical help right away if you have any very serious side effects, including sensitivity to light, vision changes e.g. blurred vision, seeing light flashes/streaks/halos, missing/blacked-out areas of vision, muscle weakness, numbness/tingling/pain of the arms/legs. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Lupus and plaquenil side effects Plaquenil Uses, Dosage & Side Effects -, Hydroxychloroquine Plaquenil Plaquenil nervous systemDoes hydroxychloroquine cause high blood pressurePlaquenil retinopathy treatmentDoes plaquenil damage kidneysWhat is hydroxychloroquine and shortness of breath The benefits of Plaq take from 2 - 6 months. However the side effects / stomach issues join the party right at the start. From day 1 or 2 this med made me, well, kinda queasy. I was not nauseous, but I was not interested in eating. Then the real fun began -- massive gas, and oh yeah the diarrhea. Imodium AD was the way I got through the day. Plaquenil side effects" Lupus Community - Support Group. Plaquenil Oral Uses, Side Effects, Interactions.. Hydroxychloroquine Plaquenil Success, Reviews and Side Effects. Other rare side effects include changes in skin pigmentation and cardiomyopathy diseases of the heart muscle. The future. Hydroxychloroquine was previously prescribed only for people whose lupus disease activity was mild in its course; if the lupus became active, steroids or immunosuppressants would be prescribed instead. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used.