See below for a comprehensive list of adverse effects. Applies to methotrexate: oral solution, oral tablet Other dosage forms: Oral route (Solution) Severe Toxic Reactions, Including Embryo-Fetal Toxicity Methotrexate can cause severe or fatal toxicities. Color vision changes associated with plaquenil toxicity Chloroquine 500mg tab Plaquenil and nerve damage Some side effects of methotrexate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Re Methotrexate vs Plaquenil side effects long term and short term The MTX dose for autoimmune disease is about 1/1000 the dose they use in cancer patients. MTX also has a long clinical history, which makes it a trustworthy drug, they'll be no "surprise" side effects. Methotrexate vs plaquenil side effects long term and short term Nov 3, 2009 I was recently diagnosed with an autoimmune disease that mainly fuses my joints together, but causes severe pain and fatigue. Methotrexate can cause embryo-fetal toxicity and fetal death. Monitor closely and modify dose or discontinue for the following toxicities: bone marrow suppression, infection, renal, gastrointestinal, hepatic, pulmonary, hypersensitivity and dermatologic. Methotrexate vs plaquenil side effects long term Bone Joint Muscle - Arthritis Methotrexate and long term use, Methotrexate vs plaquenil side effects long term and short term Plaquenil and erectile dysfunctionHydroxychloroquine 200 mg en espanolHydroxychloroquine manufacturer not workPlaquenil and tb Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Methotrexate vs Plaquenil Comparison -. Arthritis Board Index methotrexate vs plaquenil. Effects of methotrexate and hydroxychloroquine combination.. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Your rheumatologist will monitor you closely for any side effects associated with methotrexate such as liver test abnormalities, pneumonitis, or infections. Methotrexate is contraindicated in pre-existing liver conditions; making it necessary to notify your doctor of any pre-existing liver problems. Liver complications and even liver failure are possible long-term side effects of the drug.