In fact, most people with lupus have fatigue at some point in their illness. “When lupus hit, it was like running into a wall at 80 mph,” says Ann S. Hydroxychloroquine main side effect Is hydroxychloroquine sulfate an immunosuppressant Chloroquine and receptor mediated endocytosis As for the the tummy issues with Plaquenil that is probably the most common side effect with this drug. Normally, most patients get used to this drug and the tummy issues go away. Glad to hear that you're feeling some of the good side effects from the drug. It can take up to the full six months before Plaquenil to fully kick in. Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. “I had been very active my whole life, and the fatigue just knocked me flat. Utterback, Ph D, a broadcast voice specialist in Virginia who was diagnosed with lupus in 2006. Plaquenil build up How does Plaquenil work? - Sjogren's World, Hydroxychloroquine Plaquenil - Plaquenil sjogren disease doesnt work The Plaquenil Problem “Plaquenil toxicity is very distinctive,” said Michael F. Marmor, MD, professor of ophthalmology at Stanford University. Dr. Marmor, who chaired the Academy’s screening guidelines committee, said the goal in Plaquenil screening is to catch changes at a very early stage when there’s just a minimal amount of loss of. Rx Side Effects New Plaquenil Guidelines and More - American.. Plaquenil Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs. Can we reduce vascular plaque buildup? - Harvard Health. Aug 29, 2014 One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. I would agree with others.not wait to try the plaquenil. It does take time to build up in your system. The most important thing to remember when taking it is to be certain to have a baseline eye exam from an opthamologist not an optometrist and then be followed minimally once per year or every six months as it rarely can cause eye issues. WebMD explains how cholesterol is tied to plaque buildup in the arteries and the medical risks associated with both. Learn how to manage your cholesterol and slow plaque buildup.