Controlled studies in pregnant women show no evidence of fetal risk. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Animal studies show risk and human studies not available or neither animal nor human studies done. Contact the applicable plan provider for the most current information. D: Use in LIFE-THREATENING emergencies when no safer drug available. Hydroxychloroquine sulfate pharmacological class Benefits drawbacks hydroxychloroquine Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments -If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate. Both adults and children should take one dose of chloroquine per week starting at least 1 week before. traveling to the area where malaria transmission occurs. They should take one dose per week while there, and for 4 consecutive weeks after leaving. The weekly dosage for adults is 300mg base 500mg salt. For oral dosage form tablets For prevention of malaria Adults—500 milligrams mg once a week on the same day of each week starting 2 weeks before traveling to an area where malaria occurs, and continued for 8 weeks after leaving the area. Children—Dose is based on body weight and must be determined by your doctor. Active against erythrocytic forms of Plasmodium vivax & P. malariae and most strains of Plasmodium falciparum Precise mechanism not known Bioavailability: ~89% Peak plasma time: 1-2 hr Distributed widely in body tissues (eg, eyes, heart, kidneys, liver, lungs) where retention prolonged; crosses placenta; enters breast milk Partially in liver Half-life: 3-5 days Excretion: urine (~70% as unchanged drug); acidification of urine increases elimination Small amounts may be present in urine months following discontinuation of therapy The above information is provided for general informational and educational purposes only. Chloroquine for malaria prophylaxis dosing COVID-19 Prophylaxis in Healthcare workers. - Health 2019, Medicines for the Prevention of Malaria While Traveling. Generic plaquenil shortageChloroquine treatment us priceCan use of plaquenil have effect on vaccinations years laterPlaquenil with celebrex Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Chloroquine Oral Uses, Side Effects, Interactions, Pictures.. Chloroquine Oral Route Proper Use - Mayo Clinic. Hydroxychloroquine Dosage Guide with Precautions -. Aug 04, 2007 Chloroquine and proguanil, used alone or together, are the most commonly utilised drugs in prophylaxis against malaria. It is advised that prophylaxis must start 1 week before travel into an endemic area and should be continued for 4 weeks after return. The recommended dose of chloroquine for an adult is 300 mg once weekly and proguanil 200 mg. The pharmacokinetics of chloroquine were studied in healthy volunteers who received one of three different multiple-dose regimens for 3 weeks once weekly 300 mg, twice weekly 200 mg and once daily 50 mg chloroquine. Plasma concentrations of chloroquine and metabolites were determined by h.p.l.c. with fluorescence detection. When chloroquine, doxycycline, or mefloquine is used for primary prophylaxis, primaquine is usually taken during the last 2 weeks of postexposure prophylaxis. When atovaquone-proguanil is used for prophylaxis, primaquine may be taken during the final 7 days of atovaquone-proguanil, and then for an additional 7 days.