Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Pain when stopping hydroxychloroquine plaquenil Lyrica and plaquenil What is toxic dose of plaquenil Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in antigen presentation or effects on the innate immune system. This study is created by eHealthMe based on reports of 23,242 people who take Methotrexate and Plaquenil from Food and Drug Administration FDA, and is updated regularly. On eHealthMe, you can evaluate side effects and drug interactions from 15 million FDA reports. The results are personalized to your gender and age. If you are taking hydroxychloroquine for symptoms of rheumatoid arthritis, your symptoms should improve within 6 months. If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor. Once you and your doctor are sure the drug works for you. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Can you take hydroxychloroquine with methotrexate RA and Hydroxychloroquine How Effective is it for., Methotrexate and Plaquenil drug interactions - eHealthMe Visual defects hydroxychloroquineTaking plaquenil while on iron supplementsSide effects of stopping plaquenilPlaquenil 200 mg film-coated tablets Taking Folic Acid with Methotrexate for Arthritis 9 Things You Must Know This supplement can help minimize many bothersome side effects from MTX. Methotrexate is the leading disease-modifying anti-rheumatic drug DMARD given to people with rheumatoid arthritis RA and many other types of inflammatory arthritis. Taking Folic Acid with Methotrexate What Patients Need to Know. Hydroxychloroquine MedlinePlus Drug Information. Treatments for Rheumatoid Arthritis. Both medications are brought as generics, so it can run you at least $50 without insurance for each medication depending on how many methotrexate pills you would have to have; hydroxychloroqine only comes in 200mg pills which you have to take twice a day. Fortunately, I have good insurance so my co pays are only $10 each. Hope you feel better soon. Methotrexate may take longer to become effective, but USUALLY, it will take effective within the time frame you're looking at. It took me 6 months to get efficacy settled, and others longer. Take some time to search both drugs, to get a feel for what you're dealing with. Medicines that impair kidney function can increase levels of methotrexate in the body. Taking these medicines in combination with methotrexate increases the risk of bone marrow suppression.