Listing a study does not mean it has been evaluated by the U. Treatment of GBM xenografts in vivo with chloroquine (CQ), an antimalarial agent, has been shown to reduce the hypoxic fraction and sensitizes tumors to radiation. Patients with a glioblastoma (GBM) have a poor prognosis with a median survival of 14.6 months after maximal treatment with a resection and chemoradiation. Chloroquine injection Plaquenil and pink eye The mefloquine is an anti malaria drug. The whole idea of it, and the iv temodar, must mean that they are working on some new combos at MD Anderson. Maybe someone else will tell us that they have had the same regimen ordered. The mefloquine though has had a history of neurological effects like psychosis, dizziness. Chloroquine CQ is commonly used in the treatment of malaria, a disease caused by infection with the parasite Plasmodium 1. There are several decades of clinical experience with the use of CQ for the treatment of various parasitic and immune-mediated disorders, although its mechanism of action is still under investigation 1, 2. TEMODAR® temozolomide is indicated for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as maintenance treatment. 1.2 Refractory Anaplastic Astrocytoma TEMODAR is indicated for the treatment of adult patients with refractory anaplastic astrocytoma, i.e. patients who have The most common EGFR mutation in GBM (EGFRv III) is present in 50-60% of patients whose tumor shows amplification of EGFR. Epidermal growth factor receptor (EGFR) amplification or mutation is regularly observed GBM and is thought to be a major contributor to radioresistance. Chloroquine with temodor Chloroquine - Wikipedia, H-bonding and Stacking Interactions between Chloroquine and Temozolomide Macular thinning plaquenilHydroxychloroquine 200 mg tabPlaquenil rash sun Chloroquine CQ is widely known as an antimalarial and anti-rheumatoid drug. CQ is a weak, basic drug that can accumulate in acidic organelles, including lysosomes, resulting in increased vacuolar pH. Thus, CQ prevents the fusion of autophagosomes with lysosomes, inhibiting late stage autophagy. The synergistic effect of combination temozolomide and chloroquine.. HIGHLIGHTS OF PRESCRIBING INFORMATION pneumonia PCP –PCP.. Temodar Oral Uses, Side Effects, Interactions, Pictures.. Medscape - Glioblastoma and astrocytoma dosing for Temodar temozolomide, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. The results of RTOG 9802 make PCV appear to be a reasonable option, but RTOG 0424 Temodar results are just as good. My doctor's say Temodar will be as effective as PCV and more tolerable. The advantages of PCV are the RTOG 9802 survival plot for IDH1 mutations looks good, it's a multi-agent treatment, the methylation status isn't a factor, and there seems to be less risk of hypermutation. Temodar Warnings and Precautions Complications such as infections, bleeding, and anemia can occur in some people who use Temodar. These and other safety precautions should be reviewed to help minimize complications with this chemotherapy drug.