Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil and age spots Plaquenil time to work Hydroxychloroquine is used to treat discoid lupus erythematosus DLE or systemic lupus erythematosus SLE or lupus. It is also used to treat acute and chronic rheumatoid arthritis. This medicine is available only with your doctor's prescription. Discoid lupus discoid lupus erythematosus is a chronic autoimmune disease affecting the skin. It gets its name from the coin-shaped lesions it produces. This condition causes a severe rash that tends to get worse when exposed to sunlight. Discoid Lupus Erythematosus DLE Lesions resulting from DLE have a scar-like center that is often surrounded by darker hyperpigmentation, primarily affecting the ears and scalp. These lesions can lead to hair loss, which can be permanent if the DLE is long-standing and loss of hair follicles occurs. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Hydroxychloroquine discoid lupus Hydroxychloroquine Side-effects, uses, time to work, Discoid Lupus Rash Symptoms, Treatment, and Causes Plaquenil and prednisone for rheumatoid arthritisPlaquenil information sheetChloroquine maculopathy risk factorsChloroquine toxicity screening Hydroxychloroquine is used to treat discoid lupus erythematosus DLE or systemic lupus erythematosus SLE or lupus. It is also used to treat acute and chronic rheumatoid arthritis. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms Hydroxychloroquine Oral Route Description and Brand Names.. Rashes, Skin Care and Cutaneous Lupus What You Should Know. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. Hydroxychloroquine is used to treat malaria, and researchers have found that this drug also helps with lupus flares. These drugs work well with mild to moderate cases of lupus. These drugs work. Discoid lupus erythematosus DLE is a common canine autoimmune disease that usually manifests as a localized ulcerative and scarring nasal dermatitis. We report herein a generalized variant of canine DLE successfully treated with the antimalarial immunomodulator hydroxychloroquine HCQ.