Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Need eye exam yearly using plaquenil Chloroquine and proguanil dose Plaquenil sulfate 200 mg Our patient demonstrates the importance of using the new recommended screening tools for the detection of early hydroxychloroquine toxicity. 10-2 HVF, SD-OCT, autofluorescence, or mfERG might have detected the hydroxychloroquine retinal toxicity on the day of her presenting symptoms and possibly earlier, potentially limiting the amount of visual loss. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1. Plaquenil Toxicity both Eyes - Partial Bull's Eye - Discontinued 6 Years ago SD-OCT Spectral domain optical coherence tomography 2320 views 82-year-old woman was on Plaquenil from 1976 from 2005, 200 mg a day. It was discontinued because of abnormal visual fields 6 years ago. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Oct image plaquenil toxicity Retinal Physician - Hydroxychloroquine Maculopathy An., Hydroxychloroquine toxicity - EyeWiki Plaquenil worse before betterPlaquenil retinal toxicityPlaquenil online greeceChloroquine method of action The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients still experience permanent vision loss resulting from hydroxychloroquine retinopathy due to improper dosing of the drug and improper screening. Despite Plaquenil dosing recommendations, retinal toxicity.. Plaquenil Toxicity - Mild - Partial Bull's Eye Maculopathy.. Retina Today - Imaging in Hydroxychloroquine Toxicity.. Time domain OCT does not have the resolution that spectral domain OCT has, making detection of hydroxychloroquine maculopathy by this modality less sensitive. Nevertheless, time domain OCT machines are more widely available, making it important to be able to recognize toxicity with this test. In this image, the perifoveal inner segment-outer segment junction has been lost at the purple arrows. SD-OCT images demonstrated loss of photoreceptor inner segment/outer segment IS/OS junction and a downward “sink-hole” displacement of inner retinal structures in areas of hydroxychloroquine toxicity corresponding to HVF 10-2 defects and ophthalmoscopic clinical examination findings. SD-OCT scan from a 44-year-old woman with bilateral plaquenil toxicity. There is damage visible in the outer retina in a perifoveal distribution.