Chloroquine administration

Discussion in 'Aralen 250 Mg' started by Kristina, 12-Mar-2020.

  1. wServer New Member

    Chloroquine administration


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Luchters SMF, Veldhuijzen NJ, Nsanzabera D. et al. A phase I/II randomised placebo controlled study to evaluate chloroquine administration to reduce HIV-1 RNA in breast milk in an HIV-1 infected breastfeeding population the CHARGE Study. XV International Conference on AIDS; Bangkok, Thailand; July 11–16, 2004. Abstract TuPeB4499. Chloroquine Phosphate Tablets are an antimalarial and amebicidal drug. Each tablet, for oral administration, contains 250 mg chloroquine phosphate equivalent to 150 mg base or 500 mg chloroquine phosphate equivalent to 300 mg base. The results of concurrent chloroquine and ethanol administration showed that there is an increase in kidney weight and renal hypertrophy with compromised renal function indicated by the decrease in renal maximum urine concentrating ability and an increase in the serum creatinine level.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine administration

    Chloroquine MedlinePlus Drug Information, CHLOROQUINE PHOSPHATE TABLETS, USP 250 MG and 500 MG

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  7. Oral administration of 310 mg of chloroquine daily reportedly results in peak plasma concn of about 0.125 ug/mL. If 500 mg of chloroquine is administered once weekly, peak plasma concn of the drug reportedly range from 0.15-0.25 ug/mL and trough plasma concn reportedly range from 0.02-0.04 ug/mL.

    • Chloroquine phosphate C18H32ClN3O8P2 - PubChem.
    • Effects of concurrent chloroquine and ethanol..
    • Chloroquine Uses, Side Effects & Warnings -.

    Chloroquine administration is associated with an increased risk of QT prolongation and torsades de pointes TdP. If possible, avoid coadministration of amiodarone and chloroquine. Amiodarone, a Class III antiarrhythmic agent, is associated with a well-established risk of QT prolongation and TdP. Chloroquine is rapidly and almost completely absorbed from the GI tract following oral administration, and peak plasma concn of the drug are generally attained within 1-2 hr. Considerable interindividual variations in serum concn of chloroquine have been reported. Medscape - Indication-specific dosing for Aralen, Chloroquine phosphate chloroquine, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

     
  8. Balfagross Guest

    This is not a list of all drugs or health problems that interact with hydroxychloroquine. A favorable effect of hydroxychloroquine on glucose and lipid. Taking Plaquenil for Rheumatoid Arthritis Will you have Taste - impaired with Hydroxychloroquine sulfate - eHealthMe
     
  9. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Plaquenil Oral Uses, Side Effects, Interactions, Pictures. HYDROXYCHLOROQUINE - ORAL Plaquenil side effects, medical. Plaquenil Hydroxychloroquine - Side Effects, Dosage.
     
  10. alex_aaa User

    Plaquenil Hydroxychloroquine Side effects, Images, Uses. Hydroxychloroquine is not approved for use by anyone younger than 18 years old. How should I take hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox? Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Hydroxychloroquine is sometimes given only once.

    Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings.
     
  11. AlexSid Well-Known Member

    CHLOROQUINE Drug BNF content published by NICE Ocular toxicity is unlikely if the dose of chloroquine phosphate does not exceed 4 mg/kg daily equivalent to chloroquine base approx. 2.5 mg/kg daily. Cautions. Side-effects which occur at doses used in the prophylaxis or treatment of malaria are generally not serious.

    Malaria drug chloroquine potential treatment for coronavirus